Second placed Ferguslie and leaders Prestwick meet on Saturday afternoon at Meikleriggs with the winners being crowned Western Premier League champions for 2022.
Ferguslie have named an unchanged XI from week 17 for the big match while Prestwick, whose travelling support are sure to add to the atmosphere in Paisley where a big crowd is set to gather, have made one change.
With Tom Fleet unavailable, Shahzad Rafiq comes into their team.
It is shaping up to be a cracker and Ferguslie captain Riyaad Henry said: “We are looking forward to it, we are just thinking about the way we want to play.
“At training this week I could sense that the players were excited going into this one, but the main feeling I have taken from the week is that they are focused.
“That is good because we know that only our best performance with bat, ball and in the field will be good enough to beat a good Prestwick side.”
Prestwick skipper Fraser MacDonald said: “I have been over the moon with the application the guys have put in and the work ethic they have shown this season to get us to where we are at the minute.
“This team has been building over three or four years. There were three or four new players last year and it took a bit of time to adjust, but things have come together well and I am pleased that myself and others have managed to create a good culture in the dressing room.
“On paper Ferguslie are the strongest team in the league and they have a fantastic youth set-up, so we know we will have to play well to win the game this weekend, but I have faith in our guys.”
Elsewhere in round 18, third placed West of Scotland are at home to ninth placed Langside, fourth placed tackle fifth placed Uddingston at Titwood and seventh placed Dumfries host 10th placed Kelburne.
Ayr, in seventh, play at home to eighth placed Stirling County with the former building up to the Scottish Cup final on Sunday against Forfarshire.
Saturday, August 27’s fixtures:
Dumfries v Kelburne (Nunholm)
Ferguslie v Prestwick (Meikleriggs)
Clydesdale v Uddingston (Titwood)
West of Scotland v Langside (Hamilton Crescent)
Ayr v Stirling County (New Cambusdoon)